The CEBP alpha Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to CEBPA. This antibody recognizes Human, Mouse, and Rat antigen. The CEBP alpha Antibody has been validated for the following applications: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
The transcription factor C/EBP alpha (CCAAT-enhancer binding protein) is a heat-stable, sequence-specific DNA-binding protein that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP alpha regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP alpha is a basic region/leucine zipper transcription factor selectively expressed during the differentiation of liver, adipose tissue, blood cells and the endocrine pancreas. C/EBP alpha uses a bipartite structural motif to bind DNA and appears to function exclusively in terminally differentiated, growth-arrested cells. In the liver, C/EBP alpha is a transactivator of several genes, which are regulated by growth hormone. Growth hormone enhances not only the levels of C/EBP alpha mRNA and protein, but also the DNA binding activity of C/EBP alpha. C/EBP alpha functions as an important transcription factor that regulates different genes, including prolactin gene expression